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For details of the awards to be presented at the ISDB conference in 2009 click here.
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The ISDB Congress aims to retain a 'small meeting' feel and encourages scientists to speak about new and unpublished data. There will, however, be editors and journalists attending, as well as scientists who might be contributing to blogs, and it is not easy to make a meeting of this size competely private. We are therefore asking all journalists and bloggers that if they plan to report directly specific details of any of the presentations, they first seek the approval of the presenter.
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Scientific Programme
To view or print the following programme in PDF format, please click here.
| Sunday 6th September 2009 | Location | |
|---|---|---|
| 13.00 – 18.15 | Registration Speaker Preview |
Strathblane Hall Harris 1 |
| 18.15 – 20.00 | Welcome Reception & Opening of the Exhibition | Cromdale Hall Strathblane Hal |
| Monday 7th September 2009 | Location | |
|---|---|---|
| 08.00 – 18.15 | Registration Speaker Preview |
Strathblane Hall Harris 1 |
| 08.30 – 08.45 | Opening Remarks Matthew Freeman, UK |
Pentland |
| 08.45 – 09.30 | Plenary 1 Chair: Masatoshi Takeichi, Japan PL-01 Sponsored by Development Patterning transcription and cell shape change in the Drosophila embryo Eric Wieschaus, USA |
Pentland |
| 09.30 – 10.15 | Plenary 2 Chair: Masatoshi Takeichi, Japan PL-02 Sponsored by Science/AAAS Vernalization - cold-mediated epigenetic regulation of a developmental switch Caroline Dean, UK |
Pentland |
| 10.15 – 10.45 | Tea/Coffee - Sponsored by Abcam | Cromdale Hall Strathblane Hall |
| 10.45 – 13.00 | Parallel Symposium 1 – Non-coding RNA in Development Chair: Jonathan Hodgkin, UK S01-01 The diverse roles of small, non coding RNA in plants David Baulcombe, UK S01-02 Regulation of Gene Expression by MicroRNAs in C. elegans Amy Pasquinelli, USA S01-03 miRNAs couple cell cycle, cell fate and developmental timing in retinal histogenesis Federico Cremisi, Italy S01-04 piRNA biogenesis pathways in Drosophila germline cells Mikiko Siomi, Japan S01-05 AICR Lecture MicroRNA Functions Steven Cohen, Singapore |
Lomond |
| 10.45 – 13.00 | Parallel Symposium 2 – Growth Control and Tumours Chair: Tian Xu, USA S02-01 Modelling cancer in Drosophila: The junctional neoplastic tumour suppressors, Lgl, Dlg and Scrib, in cell proliferation control and tumourigenesis Helena Richardson, Australia S02-02 Mechanisms behind cancer metastasis: from Drosophila to humans and back Maria Dominguez, Spain S02-03 Blocking endocytic trafficking affects migration and polarity of melanophores in a zebrafish model of melanoma Maria Minone, Italy S02-04 Communicating with Hedgehogs: Signaling in Development & Disease Matt Scott, USA S02-05 Targeting tumor suppressor pathways to treat cancer Gerard Evan, USA |
Fintry |
| 10.45 – 13.00 | Parallel Symposium 3 – Mechanisms of Morphogenesis Chair: Ottoline Leyser, UK S03-01 Planar cell polarity: Linking developmental regulatory mechanisms to basic cellular machinery during morphogenesis. John Wallingford, USA S03-02 From cell mechanics to tissue morphogenesis Thomas Lecuit, France S03-03 High resolution live microscopy of cell motility, actin dynamics and cell-cell contacts along embryonic tissue boundaries François Fagotto, Canada S03-04 Development of Shape in Plants Enrico Coen, UK S03-05 Genetic regulation of gastrulation movements in zebrafish Lilianna Solnica-Krezel, USA |
Pentland |
| 13.00 – 14.30 | Buffet lunch/Exhibition/Poster Viewing | Cromdale Hall Strathblane Hall |
| 13.45 – 14.30 | BSDB AGM |
Lomond |
| 14.30 – 16.45 | Parallel Symposium 4 – Embryonic Induction Sponsored by Developmental Biology Chair: Angela Nieto, Spain S04-01 Calfacilitin: a new player in neural induction Claudio Stern, UK S04-02 How many ways to make a chordate: comparison of the developmental programmes of ascidians and vertebrates Patrick Lemaire, France S04-03 Dynamic patterning of the vertebrate neural tube Ana Ribeiro, UK S04-04 Mechanisms regulating differentiation onset in the embryonic axis and ES cells Kate Storey, UK S04-05 Inductive signals and transcriptional responses in neuronal fate determination Johan Ericson, Sweden |
Pentland |
| 14.30 – 16.45 | Parallel Symposium 5 – Chromatin and Epigenetics Chair: Sarah Hake, USA S05-01 Polycomb repressive complexes are required to maintain compact chromatin structure at Hox loci Wendy Bickmore, UK S05-02 Regulation of Gene Imprinting in Arabidopsis Robert Fischer, USA S05-03 Epigenetic control of hox genes colinear activation during vertebrate development Natalia Soshnikova, Switzerland S05-04 Evolutionary Diversity and Developmental Dynamics of X-chromosome Inactivation Edith Heard, France S05-05 Resetting the epigenome beyond pluripotency in the mouse germ lime Azim Surani, UK |
Fintry |
| 14.30 – 16.45 | Parallel Symposium 6 – Morphogenesis and Birth Defects Sponsored by Disease Models & Mechanisms Chair: Andy Copp, UK S06-01 Cardiac Transcription Factors in Development and Disease Richard Harvey, Australia S06-02 Neural crest and outflow tract development Jonathan Epstein, USA S06-03 The zebrafish full-of-fluid mutant identifies a secreted protein essential for lymphangiogenesis in zebrafish and humans Stefan Schulte-Merker, Netherlands S06-04 Molecular and developmental insights into the pathogenesis of the SOX9Y440X campomelic dysplasia mutation Kathy Cheah, Hong Kong S06-05 Judging a book by its cover: how facial morphology may predict underlying molecular pathology Jill Helms, USA |
Lomond |
| 16.45 – 17.15 | Tea/Coffee - Sponsored by genesis: The Journal of Genetics and Development | Cromdale Hall Strathblane Hall |
| 17.15 – 18.15 | Waddington Medal Lecture Chair: Matthew Freeman, UK |
Pentland |
| 18.15 – 20.00 | Poster Viewing Session 1 (refreshments provided) |
Cromdale Hall Strathblane Hall |
| Tuesday 8th September 2009 | Location | |
|---|---|---|
| 08.00 – 18.45 | Registration Speaker Preview |
Strathblane Hall Harris 1 |
| 08.45 – 09.30 | Plenary 3 Chair: Guy Tear, UK PL-03 Sponsored by Cell Press Signaling pathways in blastocyst lineage development Janet Rossant, Canada |
Pentland |
| 09.30 – 10.15 | Plenary 4 Chair: Guy Tear, UK PL-04 Sponsored by BSCB Regulation of self-renewal, proliferation and differentiation in an adult stem cell lineage Margaret Fuller, USA |
Pentland |
| 10.15 – 10.45 | Tea/Coffee | Cromdale Hall Strathblane |
| 10.45 – 13.00 | Parallel Symposium 7 – Asymmetry in Cells Sponsored by BSCB Chair: Liz Smythe, UK S07-01 Stem cells in the adult hypothalamus Marysia Placzek, UK S07-02 Asymmetric cell division and proliferation control in Drosophila and mouse neural stem cells Jürgen Knoblich, Austria S07-03 Asymmetric division in zebrafish neural tube is a non-stochastic event and the neuron results from the daughter that inherits the apical domain Paula Alexandre, UK S07- 04 Sara endosomes during asymmetric cell division Marcos González-Gaitan, Switzerland S07-05 Neural Stem Cell Polarity and Malignant Growth in Drosophila Cayetano González, Spain |
Fintry |
| 10.45 – 13.00 | Parallel Symposium 8 - Organogenesis Funded by the BBSRC as part of the Japan Grant Award Scheme Chair: Liz Jones, UK S08-01 Genetic regulation of anterior foregut development and repair Brigid Hogan, USA S08-02 Control of branching morphogenesis during kidney development Frank Costantini, USA S08-03 Development of land plant rooting structures Liam Dolan, UK S08-04 Multiple functions for the zinc finger transcription factor odd skipped related1 in kidney and angioblast development Iain Drummond, USA S08-05 Regulation of microtubule organization by xMID is essential for maintaining tissue integrity in Xenopus neural tube closure Makoto Suzuki, Japan |
Pentland |
| 10.45 – 13.00 | Parallel Symposium 9 – Advances in Imaging Technologies Sponsored by Zeiss Chair: Steve Wilson, UK S09-01 Imaging the Dynamics of Embryonic Development Scott Fraser, USA S09-02 Light sheet based fluorescence microscopes (LSFM, SPIM, DSLM) reduce phototoxic effects by several orders of magnitude Ernst Stelzer, Germany S09-03 Tissue Tectonics: Morphogenetic strain rates, cell shape change and intercalation Guy Blanchard, UK S09-04 OMX, a New Microscope Platform for Increased Time and Spatial Resolution John Sedat, USA S09-05 New fluorescent probes and new perspectives in bioscience Atsushi Miyawaki, Japan |
Lomond |
| 13.00 – 14.30 | Lunch/Exhibition Poster Viewing Session 2 |
Cromdale Hall Strathblane Hall |
| 14.00– 16.50 |
Workshop on
Organogenesis Funded by the BBSRC as part of the Japan Grant Award Scheme Session 1: 14.00 – 15.35 Chair: Paul Krieg, USA S08-06 Antagonistic interactions between canonical and non-canonical wnt signals regulate morphogenesis of the embryonic kidney Peter Vize, Canada S08-07 In vitro organogenesis in vertebrate development Makoto Asashima, Japan S08-08 Proteomic Analysis of Membrane Proteins Expressed Specifically in Pluripotent Mouse Embryonic Stem Cells Atushi Intoh, Japan S08-09 Construction and re-construction of the mammalian kidney Jamie Davies, UK S08-10 The role of homeodomain transcription factor HNF1B in nephrogenesis Gerhart Ryffel, Germany Tea/Coffee Break: 15.35-15.50, Cromdale Hall Session 2: 15.50 – 16.50 Chair: Peter Vize, Canada S08-11 Regulation of neural tube closure by cell adhesion molecules Naoto Ueno, Japan S08-12 The ETS family transcription factor, ETV2, activates a hierarchy of endothelial and myeloid transcription factors Paul Anthony Krieg, USA S08-13 Tissue interactions in Drosophila nephrogenesis Helen Skaer, UK |
Pentland |
| 14.30 – 16.30 | Graduate Student Symposium Chair: Liz Robertson, UK The BSDB Beddington Medal Lecture GR-01 How to change your fate Katja E. Jaeger, UK GR-02 A cross-inhibitory positive feedback mechanism establishes a robust sharp border in the forebrain Shyam Srinivasan, USA GR-03 Sonic hedgehog: a new player in temporal control of somite formation Tatiana P. Resende, Portugal GR-04 A novel regulatory network of left-right asymmetry establishment in Drosophila melanogaster: Interaction between the unconventional Myosins ID and IC and the adherens junction component DE-cadherin. Astrid G. Petzoldt, France GR-05 Essential roles for microRNAs in stem cell maintenance in the early mouse embryo Thomas Spruce, UK GR-06 Early alignment of slow muscle cells prior to migration ensures the rapid establishment of a functional larval myotome Jana Koth, UK |
Fintry |
| 14.30 – 16.30 | A Workshop on Publishing Chair: Jane Alfred, Executive Editor of Development Debbie Sweet - Developmental Cell Claudio Stern – Mechanisms of Development Marianne Bronner Fraser - Developmental Biology Jane Alfred - Development Nathalie Le Bot – Nature Cell Biology Harvey Markovitch - BMJ and publishing Ethics |
Lomond |
| 16.30 – 17.00 | Tea/Coffee | Cromdale Hall Strathblane Hall |
| 17.00 – 18.45 | Parallel Symposium 10 – Asymmetry in Organisms Chair: Ian Jackson, UK S10-01 Origin of body axes in the mouse embryo Hiroshi Hamada, Japan S10-02 Sponsored by BiomedCentral Left/right asymmetric neuronal fate specification in C.elegans Oliver Hobert, USA S10-03 Left/Right Signaling controls Tissue Polarization and Morphogenesis during Zebrafish Heart Tube Formation Salim Abdelilah-Seyfried, Germany S10-04 Helical Asymmetry and Regulation of Cortical Microtubule Arrays in Plants Takashi Hashimoto, Japan S10-05 Linking organ formation to left-right patterning in the embryonic zebrafish Miguel Concha, Chile |
Lomond |
| 17.00 – 18.45 | Parallel Symposium 11 – Behaviour and Neural Circuits Sponsored by Development Chair: K. VijayRaghavan, India S11-01 Neural Circuit Formation in Zebrafish Michael Granato, USA S11-02 Activity and signalling in the development of neural morphology and locomotion K Vijayraghavan, India S11-03 Serotonergic neurogenesis from a bipotent progenitor pool serves as a model for the coordination of neuronal birth order and identity by intrinsic genetic programs John Jacob, UK S11-04 Experience-dependent Circuit Development Hollis Cline, USA S11-05 Neural coding of behaviors in C. elegans Ikue Mori, Japan |
Fintry |
| 17.00 – 18.45 | Parallel Symposium 12 – Signalling in Development I Chair: Henry Sun, Tawian S12-01 MicroRNAs and Morphogens Alex Schier, USA S12-02 Oxygen-dependent plasticity of the Drosophila tracheal system Pablo Wappner, Argentina S12-03 The cytolinker Pigs is a target and a negative regulator of Notch signalling during epithelial somatic cell differentiation in the Drosophila ovary Katja Röper, UK S12-04 Cell cycle regulation of a Wnt receptor Christof Niehrs, Germany S12-05 TGF-beta signaling: quantitative cues, qualitative outputs Stefano Piccolo, Italy |
Pentland |
| 19.00 – 19.15 | ISDB General Assembly | Pentland |
| 19.15 – 20.15 | ISDB Ross Harrison Prize Chair: Masatoshi Takeichi, Japan |
Pentland |
| Wednesday 9th September 2009 | Location | |
|---|---|---|
| 08.00 – 18.15 | Registration Speaker Preview |
Strathblane Hall Harris 1 |
| 08.45 – 09.30 | Plenary 5 Chair: James Briscoe PL-05 Sponsored by Development Austin Smith, UK |
Pentland |
| 09.30 – 10.15 | Plenary 6 Chair: James Briscoe, UK PL-06 How to generate neurons in the adult mammalian brain - fate determinants of neurogenesis from glia Magdalena Götz, Germany |
Pentland |
| 10.15 – 10.45 | Tea/Coffee | Cromdale Hall Stratblane Hall |
| 10.45 – 13.00 | Parallel Symposium 13 – Stem Cells and Medicine Sponsored by Disease Models & Mechanisms Chair: Richard Harvey, Australia S13-02 In Vivo Visualization of Hematopoietic Stem Cell Generation Elaine Dzierzak, The Netherlands S13-04 The vascular wall as a source of stem cells in adult organs Bruno Péault, USA S13-03 HOX transcription factor regulation of adult stem/progenitor cell behavior in response to injury Kimberly Mace, UK S13-05 Harnessing epithelial stem cell potency Yann Barrandon, Switzerland S13-01 Master Heart Progenitor Cells Ken Chien, USA |
Pentland |
| 10.45 – 13.00 | Parallel Symposium 14 – Darwin and Development – Variation and Selection Sponsored by The Genetics Society Chair: Peter Holland, UK S14-01 Finding Genes Controlling Complex Traits in the Domestic Dog Elaine Ostrander, USA S14-02 Evolution under domestication: examples from maize and other crops John Doebley, USA S14-03 From trait to base pairs: Parallel evolution of pelvic reduction in three-spined sticklebacks occurs by repeated deletion of a tissue-specific pelvic enhancer at Pitx1 Yingguang Frank Chan, USA S14-04 Pecking at the Origin of Vertebrate Diversity: Insights from the Beak of the Finch Arkhat Abzhanov, USA S14-05 Genetic dissection of pollination syndromes in Petunia Cris Kuhlemeier, Switzerland |
Lomond |
| 10.45 – 13.00 | Parallel Symposium 15 – Cilia in Development and Disease Sponsored by Disease Models & Mechanisms Chair: Cheryll Tickle, UK S15-01 Cilia and Hedgehog Signaling in the Mouse Embryo Kathryn Anderson, USA S15-02 Developmental mechanisms underlying the formation of directed ciliary flow Chris Kintner, USA S15-03 Activation of Wnt/β-catenin signalling in Xenopus embryos and cancer cells by de novo lipogenesis is associated with impaired formation of the primary cilium. Kris Vleminckx, Belgium S15-04 Worms with only a single cilium..... per animal Peter Swoboda, Sweden S15-05 Cellular antennae: The role of primary cilia in human disease Phillip Beales, UK |
Fintry |
| 13.00 – 14.30 | Deli Bag Lunch/Exhibition/Poster Viewing | Cromdale Hall Strathblane Hall |
| 13.15 – 14.15 | Nikon UK Lunchtime Satellite Symposium Dkk1 and Eye: Patterning the Zebrafish Retina Joao Peres, UK CLEM - The Technology behind the Application Erik Manders, The Netherlands Nikon's Live Cell Solutions Maarten Balzar, The Netherlands |
Lomond |
| 14.30 – 16.45 | Parallel Symposium 16 – Stem Cells and Pluripotency Sponsored by UKNSCN Chair: Josh Brickman, UK S16-01 Architecture from Stem Cell Centred Feedback Networks Ben Scheres, The Netherlands S16-02 In Vivo Epithelial-to-Neuron Reprogramming in C. elegans Sophie Jarriault, France S16-03 Live imaging reveals that definitive haematopoietic stem cells emerge directly from haemogenic endothelial cells in zebrafish embryos Maria Vega Flores, New Zealand S16-04 Transcription factor network governing pluripotency Hitoshi Niwa, Japan S16-05 Conserved Function of STAT3 in Mouse and Rat Embryonic Stem Cell Self-Renewal Qi-Long Ying, USA |
Pentland |
| 14.30 – 16.45 | Parallel Symposium 17 - Darwin and Development – Patterns and Perspectives Sponsored by The Genetics Society Chair: Phil Donoghue, UK S17-01 The Evolution of Early Embryonic Patterning and Segmentation in Arthropods Michael Akam, UK S17-02 Development and the most unexpected nature of evolutionary modifications Jukka Jernvall, Finland S17-03 Differences in the wing and hindlimb transcriptomes of the Natal long-fingered bat, Miniopterus natalensis, during embryonic development Nicola Illing, South Africa S17-04 Acoel flatworms and the origin of bilaterian animals Pedro Martinez, Spain S17-05 Embryos and ancestors Phil Donoghue, UK |
Lomond |
| 14.30 – 16.45 | Parallel Symposium 18 – Modelling and Networks Sponsored by Development Chair: Mike Taylor, UK S18-01 Scaling of morphogen gradients during embryonic development Naama Barkai, Israel S18-02 Inferring Molecular Networks Jing-Dong Jackie Han, China S18-03 Shaping the early amniote embryo: an object-oriented model based on defined cell behaviours Octavian Voiculescu, UK S18-04 Synchronization of oscillating cells during embryogenesis Andrew Oates, Germany S18-05 Exploring the space of possibilities: gene networks for multicellular pattern formation James Sharpe, Spain |
Fintry |
| 16.45 – 17.15 | Tea/Coffee | Cromdale Hall Strathblane Hall |
| 17.15 – 18.15 | Plenary 7 Chair: Denis Duboule, Switzerland PL-07 Sponsored by The Genetics Society Endless Flies Most Beautiful: Cis-Regulatory Sequences and the Evolution of Animal Form Sean Carroll, USA |
Pentland |
| 18.15 – 20.00 | Poster Viewing Session 3 | Cromdale Hall Strathblane Hall |
| 20.30 – Midnight | Conference Dinner – Dynamic Earth | Dynamic Earth |
| Thursday 10th September 2009 | Location | |
|---|---|---|
| 09.00 – 15.45 | Registration Speaker Preview |
Strathblane Hall Harris 1 |
| 09.30 – 10.15 | Plenary 8 Chair: Nancy Papalopulu, UK PL-08 Sponsored by Disease Models & Mechanisms Enhancing mammalian regeneration Nadia Rosenthal, Australia |
Pentland |
| 10.15 – 10.45 | Tea/Coffee | Cromdale Hall Strathblane Hall |
| 10.45 – 13.00 | Parallel Symposium 19 – Regeneration Chair: Jeremy Brockes, UK S19-01 Planarians, stem cells, and regeneration Alejandro Sánchez Alvarado, USA S19-02 Unravelling the cellular and molecular basis of salamander limb and tail regeneration Elly Tanaka, Germany S19-03 Sodium Transport is Necessary and Sufficient for Appendage Regeneration Kelly Ai-Sun Tseng, USA S19-04 Cardiac regeneration in the zebrafish model system Ken Poss, USA S19-05 Regulation of muscle stem cell fate by Pax genes Margaret Buckingham, France |
Fintry |
| 10.45 – 13.00 | Parallel Symposium 20 – Cell Migration Sponsored by Mechanisms of Development Chair: Helen Skaer, UK S20-01 Germ cell migration in zebrafish Erez Raz, Germany S20-02 Collective migration of border cells in Drosophila Pernille Rørth, Singapore S20-03 A new effector, the Matrix-Metalloproteinase MMP9, is essential for Neural Crest onset of migration Dalit Sela-Donenfeld, Israel S20-04 Mechanisms of neuronal migration in the developing cerebral cortex Oscar Marín, Spain S20-05 Dissecting the role of extrinsic and intrinsic cues in coordinating collective cell migration Darren Gilmour, Germany |
Lomond |
| 10.45 – 13.00 | Parallel Symposium 21 – Signalling in Development II Chair: Liz Robertson, UK S21-01 Tension and mechanotransduction in embryonic morphogenesis Michel Labouesse, France S21-02 Regulation of TGF-beta signalling by Dapper2 in vertebrate development Anming Meng, China S21-03 The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass Hiroshi Sasaki, Japan S21-04 Sponsored by SDB Gene regulatory network underlying neural crest formation Marianne Bronner-Fraser, USA S21-05 Sponsored by Tecniplast Hedgehog signalling and cell diversity in the zebrafish myotome Philip Ingham, Singapore |
Pentland |
| 13.00 – 14.00 | Buffet Lunch/Exhibition/Poster Viewing | Cromdale Hall Strathblane Hall |
| 14.00 – 14.45 | Plenary 9 Chair: Matthew Freeman, UK PL-09 Scales and Stripes: Genetic analysis of the development of adult structures in the Zebrafish Christiane Nüsslein-Volhard, Germany |
Pentland |
| 14.45 – 15.30 | Plenary 10 Chair: Matthew Freeman, UK PL-10 Sponsored by Wyeth Morphogenesis through the regulation of adherens junction Masatoshi Takeichi, Japan |
Pentland |
| 15.30 – 15.45 | Closing Remarks Matthew Freeman, UK Masatoshi Takeichi, Japan |
Pentland |
Awards
The ISDB Ross Harrison Prize
Tuesday 8th September 19.15 – 20.15
The Ross Harrison Prize was established in 1981 to recognize scientists whose contributions have significantly advanced the field of developmental biology, and has come to be acknowledged as the premier recognition of achievement in the field. The Harrison Prize is awarded once every four years at a ceremony at the ISDB Congress.
The BSDB Waddington Medal
Monday 7th September 17.15 – 18.15
Conrad Waddington was a leading British embryologist and geneticist who was highly influential in the development of both subjects during the 1930s through to the 1960s. He stressed the importance of genes and the control of gene activity in embryonic development even before the chemical nature of the gene was discovered. The Waddington Medal, the only UK national award in developmental biology, is awarded for outstanding research performance, as well as services to the developmental biology community.
The BSDB Beddington Medal
Tuesday 8th September 14.30 – 16.30
The untimely death of Rosa Beddington robbed the developmental biology community of one of its greatest talents and inspirational leaders. Rosa made an enormous contribution to the field in general and to the Society in particular, so it seemed entirely appropriate that the Society should establish a lasting memorial to her. The Beddington Medal is the Society’s major award to a promising young biologist, awarded for the best PhD thesis in developmental biology submitted in the previous year. The winner will give a talk in the students' workshop at the ISDB Congress.
Nikon UK Lunchtime
Satellite Symposium
Wednesday 9th September:
13.15-14.15, Lomond Auditorium.
Dkk1 and Eye: Patterning the Zebrafish Retina
Joao Peres, UK
CLEM - The Technology behind the Application
Erik Manders, The Netherlands
Nikon’s Live Cell Solutions
Maarten Balzar, The Netherlands
Controlled Light Exposure Microscopy is a system for automatically monitoring and varying laser illumination during time-lapse studies in order to minimise the risk of cell degradation, death or bleaching.
In CLEM illumination, the fluorescent sample is determined on a per pixel basis (i.e. when and where required) by an integrated feedback process in the confocal detector. Excitation light is reduced using two strategies: The first is based on the principle that if there is no signal, then no illumination is required (for example, when imaging the background). The second detects whether there is sufficient signal to acquire an image. If so, illumination is stopped.
CLEM is ideal for live imaging as it helps to reduce photobleaching and phototoxicity; the two main limitations in live-cell microscopy. Reduced fluorescence recovery times and increased cell survival offer greater flexibility in the design of time-lapse and other live cell imaging studies.
During the presentation, Nikon will discuss CLEM in more detail including its applications and technological breakthroughs.
Delegates will be able to pick up bagged lunches in the Lomond Auditorium and take them to their seats for this lecture.